Laser ablation: Heating up the anti-tumor response in the intracranial compartment.

Journal Article (Journal Article;Review)

Immunotherapies, such as immune checkpoint inhibition (ICI), have had limited success in treating intracranial malignancies. These failures are due partly to the restrictive blood-brain-barrier (BBB), the profound tumor-dependent induction of local and systemic immunosuppression, and immune evasion exhibited by these tumors. Therefore, novel approaches must be explored that aim to overcome these stringent barriers. LITT is an emerging treatment for brain tumors that utilizes thermal ablation to kill tumor cells. LITT provides an additional therapeutic benefit by synergizing with ICI and systemic chemotherapies to strengthen the anti-tumor immune response. This synergistic relationship involves transient disruption of the BBB and local augmentation of immune function, culminating in increased CNS drug penetrance and improved anti-tumor immunity. In this review, we will provide an overview of the challenges facing immunotherapy for brain tumors, and discuss how LITT may synergize with the endogenous anti-tumor response to improve the efficacy of ICI.

Full Text

Duke Authors

Cited Authors

  • Lerner, EC; Edwards, RM; Wilkinson, DS; Fecci, PE

Published Date

  • June 2022

Published In

Volume / Issue

  • 185 /

Start / End Page

  • 114311 -

PubMed ID

  • 35489652

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2022.114311

Language

  • eng

Conference Location

  • Netherlands