Cross-Reactive Immunity Among Flaviviruses.

Journal Article (Journal Article;Review)

Flaviviruses consist of significant human pathogens responsible for hundreds of millions of infections each year. Their antigenic relationships generate immune responses that are cross-reactive to multiple flaviviruses and their widespread and overlapping geographical distributions, coupled with increases in vaccination coverage, increase the likelihood of exposure to multiple flaviviruses. Depending on the antigenic properties of the viruses to which a person is exposed, flavivirus cross-reactivity can be beneficial or could promote immune pathologies. In this review we describe our knowledge of the functional immune outcomes that arise from varied flaviviral immune statuses. The cross-reactive antibody and T cell immune responses that are protective versus pathological are also addressed.

Full Text

Duke Authors

Cited Authors

  • Rathore, APS; St John, AL

Published Date

  • 2020

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 334 -

PubMed ID

  • 32174923

Pubmed Central ID

  • PMC7054434

Electronic International Standard Serial Number (EISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2020.00334


  • eng

Conference Location

  • Switzerland