Protective and pathogenic roles for mast cells during viral infections.

Journal Article (Journal Article;Review)

Mast cells (MCs) are long-lived immune cells. They are armed with preformed mediators within granules that can be instantaneously released in response to an invading pathogen, including certain viruses. At the skin and mucosae, they initiate innate immune responses and promote the development of adaptive immune responses, through cellular recruitment or antigen presentation. However, systemic MC activation may promote immune pathologies through their vasoactive proteases and biogenic amines. Recently, MC products were identified to contribute to pathologies associated with viral hemorrhagic fever, such vascular leakage and thrombocytopenia. Similar associations of MCs with disease severity have been noted for certain respiratory viral pathogens. Here we discuss the specific MC responses to viruses and their influences on functional immune outcomes during infection.

Full Text

Duke Authors

Cited Authors

  • Rathore, AP; St John, AL

Published Date

  • October 2020

Published In

Volume / Issue

  • 66 /

Start / End Page

  • 74 - 81

PubMed ID

  • 32563779

Pubmed Central ID

  • PMC7301783

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2020.05.003


  • eng

Conference Location

  • England