Irritable Bowel Syndrome: Pathophysiology and Current Therapeutic Approaches.

Journal Article (Journal Article;Review)

Irritable bowel syndrome (IBS) is a prevalent condition affecting 10-20% of adults in most countries; IBS results in significant morbidity and health care costs. IBS is a disorder of the brain-gut axis, and recent insights into the pathophysiological mechanisms include altered bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier, and secretory properties of the gut. There remains a significant unmet need for effective treatments, particularly for the pain component of IBS, although the introduction of drugs directed at secretion, motility, and a nonabsorbable antibiotic provides an option for the bowel dysfunction in IBS.

Full Text

Duke Authors

Cited Authors

  • Camilleri, M; Ford, AC

Published Date

  • 2017

Published In

Volume / Issue

  • 239 /

Start / End Page

  • 75 - 113

PubMed ID

  • 27995391

International Standard Serial Number (ISSN)

  • 0171-2004

Digital Object Identifier (DOI)

  • 10.1007/164_2016_102


  • eng

Conference Location

  • Germany