Symbiotics in irritable bowel syndrome--better than probiotics alone?

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder associated with significant physical and psychological comorbidity. The etiology of the condition is uncertain but recent research suggests that the gut bacterial composition may play a role in its development. Therefore, manipulation of the intestinal microbiome by using probiotics and symbiotics has the potential to improve patient outcomes in IBS. RECENT FINDINGS: Numerous randomized controlled trials suggest a benefit of probiotics in the management of IBS, with a significant reduction in the likelihood of symptoms persisting after therapy, and improvements in abdominal pain, bloating and flatulence when probiotics are compared with placebo. Evidence for the effect of probiotics on quality of life is conflicting. Relatively few randomized controlled trials have examined the effect of symbiotics on outcomes in IBS, but results thus far are promising. SUMMARY: Probiotics appear to be beneficial in IBS. Data supporting the use of symbiotics is sparse. Whether symbiotics are superior to probiotics is unclear.

Full Text

Duke Authors

Cited Authors

  • Gracie, DJ; Ford, AC

Published Date

  • September 2015

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 485 - 489

PubMed ID

  • 26107141

Electronic International Standard Serial Number (EISSN)

  • 1473-6519

Digital Object Identifier (DOI)

  • 10.1097/MCO.0000000000000199


  • eng

Conference Location

  • England