Fluctuation of gastrointestinal symptoms in the community: a 10-year longitudinal follow-up study.

Journal Article (Journal Article)

BACKGROUND: There are few studies examining the stability of gastrointestinal symptoms during prolonged periods of follow-up. AIM: To examine this issue in individuals previously recruited into a community screening programme for Helicobacter pylori providing symptom data at study entry. METHODS: All traceable participants were sent dyspepsia and IBS questionnaires by post at 10 years. Symptom subgroups were assigned at baseline and 10-year follow-up. Individuals symptomatic at both time points who changed subgroup were compared with those symptomatic and remaining in the same subgroup. RESULTS: Three-thousand eight hundred and nineteen individuals provided data. At baseline, 2417 (63%) were asymptomatic or did not meet diagnostic criteria for a subgroup. Of these, 1648 (68%) remained asymptomatic at 10 years, whilst 769 (32%) reported symptoms. Of the 1402 individuals symptomatic at baseline, 404 (29%) remained in the same subgroup at 10 years, 603 (43%) changed subgroup and symptoms resolved or did not meet criteria for a subgroup in 395 (28%). Symptom stability was more likely in males [odds ratio (OR): 1.50; 99% confidence interval (CI): 0.97-2.31] and older subjects (OR per year: 1.09; 99% CI: 1.01-1.17). CONCLUSION: Of those subjects symptomatic at baseline, almost three-quarters remained symptomatic at 10 years, but over 40% changed symptom subgroup.

Full Text

Duke Authors

Cited Authors

  • Ford, AC; Forman, D; Bailey, AG; Axon, ATR; Moayyedi, P

Published Date

  • October 15, 2008

Published In

Volume / Issue

  • 28 / 8

Start / End Page

  • 1013 - 1020

PubMed ID

  • 18657131

Electronic International Standard Serial Number (EISSN)

  • 1365-2036

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2036.2008.03813.x


  • eng

Conference Location

  • England