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MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.

Publication ,  Journal Article
Andrlová, H; Miltiadous, O; Kousa, AI; Dai, A; DeWolf, S; Violante, S; Park, H-Y; Janaki-Raman, S; Gardner, R; El Daker, S; Slingerland, J ...
Published in: Sci Transl Med
May 25, 2022

Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation is unclear. In a cohort of 174 patients who underwent allo-HCT, we demonstrate that a diverse intestinal microbiome early after allo-HCT is associated with an increased number of innate-like mucosal-associated invariant T (MAIT) cells, which are in turn associated with improved overall survival and less acute graft-versus-host disease (aGVHD). Immune profiling of conventional and unconventional immune cell subsets revealed that the prevalence of Vδ2 cells, the major circulating subpopulation of γδ T cells, closely correlated with the frequency of MAIT cells and was associated with less aGVHD. Analysis of these populations using both single-cell transcriptomics and flow cytometry suggested a shift toward activated phenotypes and a gain of cytotoxic and effector functions after transplantation. A diverse intestinal microbiome with the capacity to produce activating ligands for MAIT and Vδ2 cells appeared to be necessary for the maintenance of these populations after allo-HCT. These data suggest an immunological link between intestinal microbial diversity, microbe-derived ligands, and maintenance of unconventional T cells.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

May 25, 2022

Volume

14

Issue

646

Start / End Page

eabj2829

Location

United States

Related Subject Headings

  • Mucosal-Associated Invariant T Cells
  • Ligands
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Gastrointestinal Microbiome
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Andrlová, H., Miltiadous, O., Kousa, A. I., Dai, A., DeWolf, S., Violante, S., … Markey, K. A. (2022). MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT. Sci Transl Med, 14(646), eabj2829. https://doi.org/10.1126/scitranslmed.abj2829
Andrlová, Hana, Oriana Miltiadous, Anastasia I. Kousa, Anqi Dai, Susan DeWolf, Sara Violante, Hee-Yon Park, et al. “MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.Sci Transl Med 14, no. 646 (May 25, 2022): eabj2829. https://doi.org/10.1126/scitranslmed.abj2829.
Andrlová H, Miltiadous O, Kousa AI, Dai A, DeWolf S, Violante S, et al. MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT. Sci Transl Med. 2022 May 25;14(646):eabj2829.
Andrlová, Hana, et al. “MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.Sci Transl Med, vol. 14, no. 646, May 2022, p. eabj2829. Pubmed, doi:10.1126/scitranslmed.abj2829.
Andrlová H, Miltiadous O, Kousa AI, Dai A, DeWolf S, Violante S, Park H-Y, Janaki-Raman S, Gardner R, El Daker S, Slingerland J, Giardina P, Clurman A, Gomes ALC, Nguyen C, da Silva MB, Armijo GK, Lee N, Zappasodi R, Chaligne R, Masilionis I, Fontana E, Ponce D, Cho C, Bush A, Hill L, Chao N, Sung AD, Giralt S, Vidal EH, Hosszu KK, Devlin SM, Peled JU, Cross JR, Perales M-A, Godfrey DI, van den Brink MRM, Markey KA. MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT. Sci Transl Med. 2022 May 25;14(646):eabj2829.

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

May 25, 2022

Volume

14

Issue

646

Start / End Page

eabj2829

Location

United States

Related Subject Headings

  • Mucosal-Associated Invariant T Cells
  • Ligands
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Gastrointestinal Microbiome
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences