Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance.
Publication
, Journal Article
Wu, Y; Wong, CW; Chiles, EN; Mellinger, AL; Bae, H; Jung, S; Peterson, T; Wang, J; Negrete, M; Huang, Q; Wang, L; Jang, C; Muddiman, DC ...
Published in: Cell Metab
July 5, 2022
Dietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. Although the effect of fructose on liver metabolism has been extensively studied, a significant portion of the fructose is first metabolized in the small intestine. Here, we report that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood. Chronic high systemic glycerate levels induce glucose intolerance by slowly damaging pancreatic islet cells and reducing islet sizes. Our findings provide a link between dietary fructose and diabetes that is modulated by dietary fat.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Cell Metab
DOI
EISSN
1932-7420
Publication Date
July 5, 2022
Volume
34
Issue
7
Start / End Page
1042 / 1053.e6
Location
United States
Related Subject Headings
- Islets of Langerhans
- Insulin
- Humans
- Glucose Intolerance
- Glucose
- Fructose
- Endocrinology & Metabolism
- Dietary Fats
- Diet, High-Fat
- Diabetes Mellitus, Type 2
Citation
APA
Chicago
ICMJE
MLA
NLM
Wu, Y., Wong, C. W., Chiles, E. N., Mellinger, A. L., Bae, H., Jung, S., … Shen, X. (2022). Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab, 34(7), 1042-1053.e6. https://doi.org/10.1016/j.cmet.2022.05.007
Wu, Yanru, Chi Wut Wong, Eric N. Chiles, Allyson L. Mellinger, Hosung Bae, Sunhee Jung, Ted Peterson, et al. “Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance.” Cell Metab 34, no. 7 (July 5, 2022): 1042-1053.e6. https://doi.org/10.1016/j.cmet.2022.05.007.
Wu Y, Wong CW, Chiles EN, Mellinger AL, Bae H, Jung S, et al. Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab. 2022 Jul 5;34(7):1042-1053.e6.
Wu, Yanru, et al. “Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance.” Cell Metab, vol. 34, no. 7, July 2022, pp. 1042-1053.e6. Pubmed, doi:10.1016/j.cmet.2022.05.007.
Wu Y, Wong CW, Chiles EN, Mellinger AL, Bae H, Jung S, Peterson T, Wang J, Negrete M, Huang Q, Wang L, Jang C, Muddiman DC, Su X, Williamson I, Shen X. Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab. 2022 Jul 5;34(7):1042-1053.e6.
Published In
Cell Metab
DOI
EISSN
1932-7420
Publication Date
July 5, 2022
Volume
34
Issue
7
Start / End Page
1042 / 1053.e6
Location
United States
Related Subject Headings
- Islets of Langerhans
- Insulin
- Humans
- Glucose Intolerance
- Glucose
- Fructose
- Endocrinology & Metabolism
- Dietary Fats
- Diet, High-Fat
- Diabetes Mellitus, Type 2