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Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis.

Publication ,  Journal Article
Zhou, D; Otsuki, K; Zhang, M; Chen, G; Bai, Z-S; Yu, H; Kikuchi, T; Huang, L; Chen, C-H; Li, W; Li, N
Published in: J Nat Prod
June 24, 2022

Tigliane-type diterpenoids have attracted much attention in drug discovery since they have been reported to exhibit remarkable biological effects, such as tumor-promoting, antineoplastic, and anti-HIV activities. In continuing our efforts to discover novel biologically important diterpenoids from Wikstroemia species, Wikstroemia lichiangensis was investigated phytochemically for the first time. As a result, four new (1-4) and one known (5) tigliane-type diterpenoid were isolated, and their structures were elucidated by spectroscopic data analysis. Tiglianes (1-5) showed potent anti-HIV activity against HIV-1 infection of MT4 lymphocytes with IC50 values of 1.1-65.4 nM.

Duke Scholars

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

June 24, 2022

Volume

85

Issue

6

Start / End Page

1658 / 1664

Location

United States

Related Subject Headings

  • Wikstroemia
  • Plant Components, Aerial
  • Phorbols
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Diterpenes
  • 4208 Traditional, complementary and integrative medicine
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences
 

Citation

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Zhou, D., Otsuki, K., Zhang, M., Chen, G., Bai, Z.-S., Yu, H., … Li, N. (2022). Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis. J Nat Prod, 85(6), 1658–1664. https://doi.org/10.1021/acs.jnatprod.1c01195
Zhou, Di, Kouharu Otsuki, Mi Zhang, Gang Chen, Zi-Song Bai, Haotian Yu, Takashi Kikuchi, et al. “Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis.J Nat Prod 85, no. 6 (June 24, 2022): 1658–64. https://doi.org/10.1021/acs.jnatprod.1c01195.
Zhou D, Otsuki K, Zhang M, Chen G, Bai Z-S, Yu H, et al. Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis. J Nat Prod. 2022 Jun 24;85(6):1658–64.
Zhou, Di, et al. “Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis.J Nat Prod, vol. 85, no. 6, June 2022, pp. 1658–64. Pubmed, doi:10.1021/acs.jnatprod.1c01195.
Zhou D, Otsuki K, Zhang M, Chen G, Bai Z-S, Yu H, Kikuchi T, Huang L, Chen C-H, Li W, Li N. Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis. J Nat Prod. 2022 Jun 24;85(6):1658–1664.
Journal cover image

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

June 24, 2022

Volume

85

Issue

6

Start / End Page

1658 / 1664

Location

United States

Related Subject Headings

  • Wikstroemia
  • Plant Components, Aerial
  • Phorbols
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Diterpenes
  • 4208 Traditional, complementary and integrative medicine
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences