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Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry.

Publication ,  Journal Article
Symons, JM; Chua, AN; Somers, MJG; Baum, MA; Bunchman, TE; Benfield, MR; Brophy, PD; Blowey, D; Fortenberry, JD; Chand, D; Flores, FX ...
Published in: Clin J Am Soc Nephrol
July 2007

BACKGROUND: This article reports demographic characteristics and intensive care unit survival for 344 patients from the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry, a voluntary multicenter observational network. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Ages were newborn to 25 yr, 58% were male, and weights were 1.3 to 160 kg. Patients spent a median of 2 d in the intensive care unit before CRRT (range 0 to 135). At CRRT initiation, 48% received diuretics and 66% received vasoactive drugs. Mean blood flow was 97.9 ml/min (range 10 to 350 ml/min; median 100 ml/min); mean blood flow per body weight was 5 ml/min per kg (range 0.6 to 53.6 ml/min per kg; median 4.1 ml/min per kg). Days on CRRT were <1 to 83 (mean 9.1; median 6). A total of 56% of circuits had citrate anticoagulation, 37% had heparin, and 7% had no anticoagulation. RESULTS: Overall survival was 58%; survival differed across participating centers. Survival was lowest (51%) when CRRT was started for combined fluid overload and electrolyte imbalance. There was better survival in patients with principal diagnoses of drug intoxication (100%), renal disease (84%), tumor lysis syndrome (83%), and inborn errors of metabolism (73%); survival was lowest in liver disease/transplant (31%), pulmonary disease/transplant (45%), and bone marrow transplant (45%). Overall survival was better for children who weighed >10 kg (63 versus 43%; P = 0.001) and for those who were older than 1 yr (62 versus 44%; P = 0.007). CONCLUSIONS: CRRT can be used successfully for a wide range of critically ill children. Survival is best for those who have acute, specific abnormalities and lack multiple organ involvement; sicker patients with selected diagnoses may have lower survival. Center differences might suggest opportunities to define best practices with future study.

Duke Scholars

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

July 2007

Volume

2

Issue

4

Start / End Page

732 / 738

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Replacement Therapy
  • Registries
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Demography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Symons, J. M., Chua, A. N., Somers, M. J. G., Baum, M. A., Bunchman, T. E., Benfield, M. R., … Goldstein, S. L. (2007). Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol, 2(4), 732–738. https://doi.org/10.2215/CJN.03200906
Symons, Jordan M., Annabelle N. Chua, Michael J. G. Somers, Michelle A. Baum, Timothy E. Bunchman, Mark R. Benfield, Patrick D. Brophy, et al. “Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry.Clin J Am Soc Nephrol 2, no. 4 (July 2007): 732–38. https://doi.org/10.2215/CJN.03200906.
Symons JM, Chua AN, Somers MJG, Baum MA, Bunchman TE, Benfield MR, et al. Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol. 2007 Jul;2(4):732–8.
Symons, Jordan M., et al. “Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry.Clin J Am Soc Nephrol, vol. 2, no. 4, July 2007, pp. 732–38. Pubmed, doi:10.2215/CJN.03200906.
Symons JM, Chua AN, Somers MJG, Baum MA, Bunchman TE, Benfield MR, Brophy PD, Blowey D, Fortenberry JD, Chand D, Flores FX, Hackbarth R, Alexander SR, Mahan J, McBryde KD, Goldstein SL. Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol. 2007 Jul;2(4):732–738.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

July 2007

Volume

2

Issue

4

Start / End Page

732 / 738

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Replacement Therapy
  • Registries
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Demography