Breaking barriers in postoperative delirium.

Journal Article (Editorial)

Systemic perturbations such as peripheral surgical trauma induce neurovascular, inflammatory, and cognitive changes. The blood-brain barrier is a key interface between the periphery and the central nervous system, and is critically involved in regulating neuroimmune interactions to maintain overall homeostasis. Mounting evidence suggests that blood-brain barrier dysfunction is a hallmark of ageing and multiple neurological conditions including Alzheimer's disease. We discuss a recent study published in the British Journal of Anaesthesia that describes blood-brain barrier changes and neuroinflammation in patients with postoperative delirium after non-intracranial surgery.

Full Text

Duke Authors

Cited Authors

  • Terrando, N; Akassoglou, K

Published Date

  • August 2022

Published In

Volume / Issue

  • 129 / 2

Start / End Page

  • 147 - 150

PubMed ID

  • 35718561

Electronic International Standard Serial Number (EISSN)

  • 1471-6771

Digital Object Identifier (DOI)

  • 10.1016/j.bja.2022.05.004


  • eng

Conference Location

  • England