Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol

Journal Article (Journal Article)

Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.

Full Text

Duke Authors

Cited Authors

  • Berardi, G; Frey-Law, L; Sluka, KA; Bayman, EO; Coffey, CS; Ecklund, D; Vance, CGT; Dailey, DL; Burns, J; Buvanendran, A; McCarthy, RJ; Jacobs, J; Zhou, XJ; Wixson, R; Balach, T; Brummett, CM; Clauw, D; Colquhoun, D; Harte, SE; Harris, RE; Williams, DA; Chang, AC; Waljee, J; Fisch, KM; Jepsen, K; Laurent, LC; Olivier, M; Langefeld, CD; Howard, TD; Fiehn, O; Jacobs, JM; Dakup, P; Qian, WJ; Swensen, AC; Lokshin, A; Lindquist, M; Caffo, BS; Crainiceanu, C; Zeger, S; Kahn, A; Wager, T; Taub, M; Ford, J; Sutherland, SP; Wandner, LD

Published Date

  • April 25, 2022

Published In

Volume / Issue

  • 9 /

Electronic International Standard Serial Number (EISSN)

  • 2296-858X

Digital Object Identifier (DOI)

  • 10.3389/fmed.2022.849214

Citation Source

  • Scopus