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ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Publication ,  Journal Article
Robbins, CB; Akrobetu, D; Ma, JP; Stinnett, SS; Soundararajan, S; Liu, AJ; Johnson, KG; Grewal, DS; Fekrat, S
Published in: Retina
July 1, 2022

PURPOSE: To assess retinal microvascular alterations in individuals with amnestic mild cognitive impairment (MCI) and nonamnestic MCI. METHODS: One hundred twelve eyes of 59 amnestic MCI participants, 32 eyes of 17 nonamnestic MCI participants, and 111 eyes of 56 controls with normal cognition were included. Optical coherence tomography angiography vessel density and perfusion density in the Early Treatment Diabetic Retinopathy Study 3-mm circle and ring were assessed. Retinal thickness parameters including retinal nerve fiber layer thickness, ganglion cell-inner plexiform layer thickness, central subfield thickness, and subfoveal choroidal thickness were also analyzed. Multivariable generalized estimating equations were used for statistical analysis. RESULTS: Perfusion density in the 3-mm inner ring was significantly lower in amnestic MCI patients when compared with nonamnestic MCI participants (0.29 ± 0.03 vs. 0.34 ± 0.09, P = 0.025) and controls with normal cognition (0.29 ± 0.03 vs. 0.39 ± 0.02, P < 0.001), after adjustment for age and sex as covariates. Vessel density, retinal nerve fiber layer thickness, ganglion cell-inner plexiform layer thickness, central subfield thickness, and subfoveal choroidal thickness did not differ among or between diagnostic groups. CONCLUSION: Perfusion density was significantly reduced in individuals with amnestic MCI, compared with those with nonamnestic MCI and controls with normal cognition.

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Published In

Retina

DOI

EISSN

1539-2864

Publication Date

July 1, 2022

Volume

42

Issue

7

Start / End Page

1338 / 1346

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Humans
  • Cognitive Dysfunction
  • Angiography
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

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MLA
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Robbins, C. B., Akrobetu, D., Ma, J. P., Stinnett, S. S., Soundararajan, S., Liu, A. J., … Fekrat, S. (2022). ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina, 42(7), 1338–1346. https://doi.org/10.1097/IAE.0000000000003458
Robbins, Cason B., Dennis Akrobetu, Justin P. Ma, Sandra S. Stinnett, Srinath Soundararajan, Andy J. Liu, Kim G. Johnson, Dilraj S. Grewal, and Sharon Fekrat. “ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.Retina 42, no. 7 (July 1, 2022): 1338–46. https://doi.org/10.1097/IAE.0000000000003458.
Robbins CB, Akrobetu D, Ma JP, Stinnett SS, Soundararajan S, Liu AJ, et al. ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2022 Jul 1;42(7):1338–46.
Robbins, Cason B., et al. “ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.Retina, vol. 42, no. 7, July 2022, pp. 1338–46. Pubmed, doi:10.1097/IAE.0000000000003458.
Robbins CB, Akrobetu D, Ma JP, Stinnett SS, Soundararajan S, Liu AJ, Johnson KG, Grewal DS, Fekrat S. ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2022 Jul 1;42(7):1338–1346.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

July 1, 2022

Volume

42

Issue

7

Start / End Page

1338 / 1346

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Humans
  • Cognitive Dysfunction
  • Angiography
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry