Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil.

Journal Article (Journal Article)

Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.

Full Text

Duke Authors

Cited Authors

  • Rocha, GDS; Farias, AS; Alcântara, JA; Machado, VA; Murta, F; Val, F; Cristino, JS; Santos, AC; Ferreira, MB; Marques, L; Rocha, YV; Sachett, A; Almeida, MC; Alencar, A; Brasileiro, L; Carvalho, ÉDS; Bisneto, PF; Lacerda, M; Tupetz, A; Staton, CA; Vissoci, JRN; Teixeira, E; Gerardo, CJ; Wen, FH; Sachett, J; Monteiro, W

Published Date

  • May 28, 2022

Published In

Volume / Issue

  • 14 / 6

PubMed ID

  • 35737037

Pubmed Central ID

  • PMC9229773

Electronic International Standard Serial Number (EISSN)

  • 2072-6651

Digital Object Identifier (DOI)

  • 10.3390/toxins14060376


  • eng

Conference Location

  • Switzerland