Scholars@Duke publication: G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

Publication , Journal Article

Bose, S; Huang, Q; Ma, Y; Wang, L; Rivera, GO; Ouyang, Y; Whitaker, R; Gibson, RA; Kontos, CD; Berchuck, A; Previs, RA; Shen, X

Published in: Cell Rep

June 28, 2022

Published version (DOI) Link to item

Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of OC-related deaths. In particular, OC tumors preferentially metastasize to and proliferate rapidly in the omentum. Here, we show that metastatic OC cells experience increased oxidative stress in the omental microenvironment. Metabolic reprogramming, including upregulation of the pentose phosphate pathway (PPP), a key cellular redox homeostasis mechanism, allows OC cells to compensate for this challenge. Inhibition of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, reduces tumor burden in pre-clinical models of OC, suggesting that this adaptive metabolic dependency is important for OC omental metastasis.

Duke Scholars

Author Christopher Dale Kontos Medicine, Cardiology

Author Rebecca Gibson

Author Andrew Berchuck Obstetrics and Gynecology, Gynecologic Oncology

Author Rebecca A Previs Obstetrics and Gynecology, Gynecologic Oncology

Author Xiling Shen Pathology

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Published In

Cell Rep

DOI

10.1016/j.celrep.2022.111012

EISSN

2211-1247

Publication Date

June 28, 2022

Volume

Issue

Start / End Page

111012

Location

United States

Related Subject Headings

Tumor Microenvironment
Pentose Phosphate Pathway
Oxidative Stress
Ovarian Neoplasms
Omentum
Humans
Glucosephosphate Dehydrogenase
Female
Carcinoma, Ovarian Epithelial
31 Biological sciences

Citation

APA

Chicago

ICMJE

MLA

NLM

Bose, S., Huang, Q., Ma, Y., Wang, L., Rivera, G. O., Ouyang, Y., … Shen, X. (2022). G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment. Cell Rep, 39(13), 111012. https://doi.org/10.1016/j.celrep.2022.111012

Bose, Shree, Qiang Huang, Yunhan Ma, Lihua Wang, Grecia O. Rivera, Yunxin Ouyang, Regina Whitaker, et al. “G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.” Cell Rep 39, no. 13 (June 28, 2022): 111012. https://doi.org/10.1016/j.celrep.2022.111012.

Bose S, Huang Q, Ma Y, Wang L, Rivera GO, Ouyang Y, et al. G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment. Cell Rep. 2022 Jun 28;39(13):111012.

Bose, Shree, et al. “G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.” Cell Rep, vol. 39, no. 13, June 2022, p. 111012. Pubmed, doi:10.1016/j.celrep.2022.111012.

Bose S, Huang Q, Ma Y, Wang L, Rivera GO, Ouyang Y, Whitaker R, Gibson RA, Kontos CD, Berchuck A, Previs RA, Shen X. G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment. Cell Rep. 2022 Jun 28;39(13):111012.

Published In

Cell Rep

DOI

10.1016/j.celrep.2022.111012

EISSN

2211-1247

Publication Date

June 28, 2022

Volume

Issue

Start / End Page

111012

Location

United States

Related Subject Headings

Tumor Microenvironment
Pentose Phosphate Pathway
Oxidative Stress
Ovarian Neoplasms
Omentum
Humans
Glucosephosphate Dehydrogenase
Female
Carcinoma, Ovarian Epithelial
31 Biological sciences