Wrestling with Chromosomes: The Roles of SUMO During Meiosis.

Book Section

Meiosis is a specialized form of cell division required for the formation of haploid gametes and therefore is essential for successful sexual reproduction. Various steps are exquisitely coordinated to ensure accurate chromosome segregation during meiosis, thereby promoting the formation of haploid gametes from diploid cells. Recent studies are demonstrating that an important form of regulation during meiosis is exerted by the post-translational protein modification known as sumoylation. Here, we review and discuss the various critical steps of meiosis in which SUMO-mediated regulation has been implicated thus far. These include the maintenance of meiotic centromeric heterochromatin , meiotic DNA double-strand break repair and homologous recombination, centromeric coupling, and the assembly of a proteinaceous scaffold between homologous chromosomes known as the synaptonemal complex.

Full Text

Duke Authors

Cited Authors

  • Nottke, AC; Kim, H-M; Colaiácovo, MP

Published Date

  • January 2017

Volume / Issue

  • 963 /

Start / End Page

  • 185 - 196

PubMed ID

  • 28197913

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-50044-7_11