Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.

Journal Article (Review;Journal Article)

The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti-parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio of Pols α, δ and ϵ, with the assistance of Pol ζ and Y-family Pols at difficult DNA template structures or sites of DNA damage. The parameters of the synthesis at a given location are dictated by the quality and quantity of nucleotides in the pools, replication fork architecture, transcription status, regulation of Pol switches, and structure of chromatin. The result of these transactions is a subject of survey and editing by DNA repair.

Full Text

Duke Authors

Cited Authors

  • Waisertreiger, IS-R; Liston, VG; Menezes, MR; Kim, H-M; Lobachev, KS; Stepchenkova, EI; Tahirov, TH; Rogozin, IB; Pavlov, YI

Published Date

  • December 2012

Published In

Volume / Issue

  • 53 / 9

Start / End Page

  • 699 - 724

PubMed ID

  • 23055184

Pubmed Central ID

  • PMC3893020

Electronic International Standard Serial Number (EISSN)

  • 1098-2280

International Standard Serial Number (ISSN)

  • 0893-6692

Digital Object Identifier (DOI)

  • 10.1002/em.21735


  • eng