Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Journal Article (Journal Article)

The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

Full Text

Duke Authors

Cited Authors

  • Alghamdi, NJ; Balaraman, L; Emhoff, KA; Salem, AMH; Wei, R; Zhou, A; Boyd, WC

Published Date

  • September 10, 2019

Published In

Volume / Issue

  • 4 / 11

Start / End Page

  • 14503 - 14510

Electronic International Standard Serial Number (EISSN)

  • 2470-1343

Digital Object Identifier (DOI)

  • 10.1021/acsomega.9b01684

Citation Source

  • Scopus