Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells
The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.
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- 4004 Chemical engineering
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0912 Materials Engineering
- 0904 Chemical Engineering
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- 4004 Chemical engineering
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0912 Materials Engineering
- 0904 Chemical Engineering