Adiponectin preserves metabolic fitness during aging.

Journal Article (Journal Article)

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.

Full Text

Duke Authors

Cited Authors

  • Li, N; Zhao, S; Zhang, Z; Zhu, Y; Gliniak, CM; Vishvanath, L; An, YA; Wang, M-Y; Deng, Y; Zhu, Q; Shan, B; Sherwood, A; Onodera, T; Oz, OK; Gordillo, R; Gupta, RK; Liu, M; Horvath, TL; Dixit, VD; Scherer, PE

Published Date

  • April 27, 2021

Published In

Volume / Issue

  • 10 /

PubMed ID

  • 33904399

Pubmed Central ID

  • PMC8099426

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.65108

Language

  • eng

Conference Location

  • England