Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.

Journal Article (Journal Article)

Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.

Full Text

Duke Authors

Cited Authors

  • Wang, QA; Song, A; Chen, W; Schwalie, PC; Zhang, F; Vishvanath, L; Jiang, L; Ye, R; Shao, M; Tao, C; Gupta, RK; Deplancke, B; Scherer, PE

Published Date

  • August 7, 2018

Published In

Volume / Issue

  • 28 / 2

Start / End Page

  • 282 - 288.e3

PubMed ID

  • 29909970

Pubmed Central ID

  • PMC6535147

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2018.05.022

Language

  • eng

Conference Location

  • United States