Tracking adipogenesis during white adipose tissue development, expansion and regeneration.

Journal Article (Journal Article)

White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.

Full Text

Duke Authors

Cited Authors

  • Wang, QA; Tao, C; Gupta, RK; Scherer, PE

Published Date

  • October 2013

Published In

Volume / Issue

  • 19 / 10

Start / End Page

  • 1338 - 1344

PubMed ID

  • 23995282

Pubmed Central ID

  • PMC4075943

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

Digital Object Identifier (DOI)

  • 10.1038/nm.3324


  • eng

Conference Location

  • United States