HNF-4alpha: from MODY to late-onset type 2 diabetes.
Journal Article (Journal Article;Review)
Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.
- Gupta, RK; Kaestner, KH
- November 2004
Volume / Issue
- 10 / 11
Start / End Page
- 521 - 524
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)