HNF-4alpha: from MODY to late-onset type 2 diabetes.

Journal Article (Journal Article;Review)

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.

Full Text

Duke Authors

Cited Authors

  • Gupta, RK; Kaestner, KH

Published Date

  • November 2004

Published In

Volume / Issue

  • 10 / 11

Start / End Page

  • 521 - 524

PubMed ID

  • 15519277

International Standard Serial Number (ISSN)

  • 1471-4914

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2004.09.004


  • eng

Conference Location

  • England