C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.

Journal Article (Journal Article)

The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process that could be of great importance for regenerative medicine. Using a unique RT-PCR-based screen against all transcriptional components, we showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the increased CITED4. Importantly, mice with reduced cardiac C/EBPβ levels displayed substantial resistance to cardiac failure upon pressure overload. These data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBPβ is a central signal in physiologic hypertrophy and proliferation.

Full Text

Duke Authors

Cited Authors

  • Boström, P; Mann, N; Wu, J; Quintero, PA; Plovie, ER; Panáková, D; Gupta, RK; Xiao, C; MacRae, CA; Rosenzweig, A; Spiegelman, BM

Published Date

  • December 23, 2010

Published In

Volume / Issue

  • 143 / 7

Start / End Page

  • 1072 - 1083

PubMed ID

  • 21183071

Pubmed Central ID

  • PMC3035164

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2010.11.036

Language

  • eng

Conference Location

  • United States