Contemporary management of pain in cirrhosis: Toward precision therapy for pain.

Journal Article (Journal Article)

Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health-related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding, renal injury, falls, and hepatic encephalopathy. Chronic pain can be categorized mechanistically into three pain types: nociceptive, neuropathic, and nociplastic, each responsive to different therapies. By discussing the identification, etiology, and treatment of these three mechanistic pain descriptors with a focus on specific challenges in patients with cirrhosis, we provide a framework for better tailoring treatments, including nonpharmacologic therapies, to patients' needs.

Full Text

Duke Authors

Cited Authors

  • Holman, A; Parikh, N; Clauw, DJ; Williams, DA; Tapper, EB

Published Date

  • January 1, 2023

Published In

Volume / Issue

  • 77 / 1

Start / End Page

  • 290 - 304

PubMed ID

  • 35665522

Pubmed Central ID

  • PMC9970025

Electronic International Standard Serial Number (EISSN)

  • 1527-3350

Digital Object Identifier (DOI)

  • 10.1002/hep.32598


  • eng

Conference Location

  • United States