Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Journal Article (Journal Article;Review)

Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease.

Full Text

Duke Authors

Cited Authors

  • Rudin, CM; Poirier, JT; Byers, LA; Dive, C; Dowlati, A; George, J; Heymach, JV; Johnson, JE; Lehman, JM; MacPherson, D; Massion, PP; Minna, JD; Oliver, TG; Quaranta, V; Sage, J; Thomas, RK; Vakoc, CR; Gazdar, AF

Published Date

  • May 2019

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 289 - 297

PubMed ID

  • 30926931

Pubmed Central ID

  • PMC6538259

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/s41568-019-0133-9


  • eng

Conference Location

  • England