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Overview of the neonatal research network: History, contributions, challenges, and future.

Publication ,  Journal Article
Watterberg, KL; Carlo, WA; Brion, LP; Cotten, CM; Higgins, RD
Published in: Semin Perinatol
November 2022

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network (NRN) has been a leader in neonatal research since 1986. In this chapter we review its history and achievements in (1) continuing observation of populations, treatments, short and longer-term outcomes, and trends over time; (2) "negative studies" (trials with non-significant primary outcomes) and trials stopped for futility or adverse events, which have influenced practice and subsequent trial design; and, (3) landmark trials that have changed neonatal care. Its consistent framework has enabled the NRN to be a pioneer in conducting longer-term, school-age follow-up. Leveraging its established infrastructure, the NRN has also partnered with other NIH institutes, governmental agencies, and industry to more effectively advance neonatal care. As current examples of its evolution with changing times, the Network has instituted a process to open specific network trials to external institutions and is adding a parent and participant component to future endeavors.

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Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

November 2022

Volume

46

Issue

7

Start / End Page

151634

Location

United States

Related Subject Headings

  • United States
  • Obstetrics & Reproductive Medicine
  • National Institute of Child Health and Human Development (U.S.)
  • Infant, Newborn
  • Humans
  • Forecasting
  • Child
  • 4204 Midwifery
  • 3215 Reproductive medicine
  • 3213 Paediatrics
 

Citation

APA
Chicago
ICMJE
MLA
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Watterberg, K. L., Carlo, W. A., Brion, L. P., Cotten, C. M., & Higgins, R. D. (2022). Overview of the neonatal research network: History, contributions, challenges, and future. Semin Perinatol, 46(7), 151634. https://doi.org/10.1016/j.semperi.2022.151634
Watterberg, Kristi L., Waldemar A. Carlo, Luc P. Brion, C Michael Cotten, and Rosemary D. Higgins. “Overview of the neonatal research network: History, contributions, challenges, and future.Semin Perinatol 46, no. 7 (November 2022): 151634. https://doi.org/10.1016/j.semperi.2022.151634.
Watterberg KL, Carlo WA, Brion LP, Cotten CM, Higgins RD. Overview of the neonatal research network: History, contributions, challenges, and future. Semin Perinatol. 2022 Nov;46(7):151634.
Watterberg, Kristi L., et al. “Overview of the neonatal research network: History, contributions, challenges, and future.Semin Perinatol, vol. 46, no. 7, Nov. 2022, p. 151634. Pubmed, doi:10.1016/j.semperi.2022.151634.
Watterberg KL, Carlo WA, Brion LP, Cotten CM, Higgins RD. Overview of the neonatal research network: History, contributions, challenges, and future. Semin Perinatol. 2022 Nov;46(7):151634.
Journal cover image

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

November 2022

Volume

46

Issue

7

Start / End Page

151634

Location

United States

Related Subject Headings

  • United States
  • Obstetrics & Reproductive Medicine
  • National Institute of Child Health and Human Development (U.S.)
  • Infant, Newborn
  • Humans
  • Forecasting
  • Child
  • 4204 Midwifery
  • 3215 Reproductive medicine
  • 3213 Paediatrics