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NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial.

Publication ,  Journal Article
Moll-Bernardes, R; Fortier, SC; Sousa, AS; Lopes, RD; Vera, N; Conde, L; Feldman, A; Arruda, G; Cabral-Castro, M; Albuquerque, DC; Paula, TC ...
Published in: J Clin Med
June 27, 2022

Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications.

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Published In

J Clin Med

DOI

ISSN

2077-0383

Publication Date

June 27, 2022

Volume

11

Issue

13

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences
 

Citation

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MLA
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Moll-Bernardes, R., Fortier, S. C., Sousa, A. S., Lopes, R. D., Vera, N., Conde, L., … Medei, E. (2022). NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. J Clin Med, 11(13). https://doi.org/10.3390/jcm11133713
Moll-Bernardes, Renata, Sérgio C. Fortier, Andréa S. Sousa, Renato D. Lopes, Narendra Vera, Luciana Conde, André Feldman, et al. “NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial.J Clin Med 11, no. 13 (June 27, 2022). https://doi.org/10.3390/jcm11133713.
Moll-Bernardes R, Fortier SC, Sousa AS, Lopes RD, Vera N, Conde L, et al. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. J Clin Med. 2022 Jun 27;11(13).
Moll-Bernardes, Renata, et al. “NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial.J Clin Med, vol. 11, no. 13, June 2022. Pubmed, doi:10.3390/jcm11133713.
Moll-Bernardes R, Fortier SC, Sousa AS, Lopes RD, Vera N, Conde L, Feldman A, Arruda G, Cabral-Castro M, Albuquerque DC, Paula TC, Furquim T, Loures VA, Giusti K, Oliveira N, Macedo A, Barros E Silva P, De Luca F, Kotsugai M, Domiciano R, Silva FA, Santos MF, Souza OF, Bozza FA, Luiz RR, Medei E. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. J Clin Med. 2022 Jun 27;11(13).

Published In

J Clin Med

DOI

ISSN

2077-0383

Publication Date

June 27, 2022

Volume

11

Issue

13

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences