ONS Guidelines™ to Support Patient Adherence to Oral Anticancer Medications.

Journal Article (Journal Article)


This evidence-based guideline intends to support patients, clinicians, and others regarding interventions and processes to support patient adherence to oral anticancer medications (OAMs).

Methodologic approach

A panel of healthcare professionals and patient representatives developed a clinical practice guideline to support patients taking OAMs. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) methodology and criteria for trustworthy guidelines were followed. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. A quantitative or narrative synthesis of the evidence was completed. Certainty of the evidence was assessed using GRADE.


The panel agreed on recommendations and suggested an adherence risk assessment, education addressing adherence, ongoing assessment, proactive follow-up, coaching, and motivational interviewing in addition to usual care. The panel suggested the implementation of a structured OAM program.

Implications for nursing

As cancer treatment shifts from clinic to home settings, interventions and programs to support patients on OAMs are needed.

Full Text

Duke Authors

Cited Authors

  • Belcher, SM; Mackler, E; Muluneh, B; Ginex, PK; Anderson, MK; Bettencourt, E; DasGupta, RK; Elliott, J; Hall, E; Karlin, M; Kostoff, D; Marshall, VK; Millisor, VE; Molnar, M; Schneider, SM; Tipton, J; Yackzan, S; LeFebvre, KB; Sivakumaran, K; Waseem, H; Morgan, RL

Published Date

  • June 2022

Published In

Volume / Issue

  • 49 / 4

Start / End Page

  • 279 - 295

PubMed ID

  • 35788731

Pubmed Central ID

  • PMC9303042

Electronic International Standard Serial Number (EISSN)

  • 1538-0688

International Standard Serial Number (ISSN)

  • 0190-535X

Digital Object Identifier (DOI)

  • 10.1188/22.onf.279-295


  • eng