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A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients.

Publication ,  Journal Article
Azar, MM; Turbett, S; Gaston, D; Gitman, M; Razonable, R; Koo, S; Hanson, K; Kotton, C; Silveira, F; Banach, DB; Basu, SS; Bhaskaran, A ...
Published in: Am J Transplant
December 2022

The last decade has seen an explosion of advanced assays for the diagnosis of infectious diseases, yet evidence-based recommendations to inform their optimal use in the care of transplant recipients are lacking. A consensus conference sponsored by the American Society of Transplantation (AST) was convened on December 7, 2021, to define the utility of novel infectious disease diagnostics in organ transplant recipients. The conference represented a collaborative effort by experts in transplant infectious diseases, diagnostic stewardship, and clinical microbiology from centers across North America to evaluate current uses, unmet needs, and future directions for assays in 5 categories including (1) multiplex molecular assays, (2) rapid antimicrobial resistance detection methods, (3) pathogen-specific T-cell reactivity assays, (4) next-generation sequencing assays, and (5) mass spectrometry-based assays. Participants reviewed and appraised available literature, determined assay advantages and limitations, developed best practice guidance largely based on expert opinion for clinical use, and identified areas of future investigation in the setting of transplantation. In addition, attendees emphasized the need for well-designed studies to generate high-quality evidence needed to guide care, identified regulatory and financial barriers, and discussed the role of regulatory agencies in facilitating research and implementation of these assays. Findings and consensus statements are presented.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2022

Volume

22

Issue

12

Start / End Page

3150 / 3169

Location

United States

Related Subject Headings

  • Transplants
  • Transplant Recipients
  • Surgery
  • Organ Transplantation
  • North America
  • Humans
  • Consensus
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Azar, M. M., Turbett, S., Gaston, D., Gitman, M., Razonable, R., Koo, S., … Transplant ID Diagnostics Consensus Conference Working Group, . (2022). A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients. Am J Transplant, 22(12), 3150–3169. https://doi.org/10.1111/ajt.17147
Azar, Marwan M., Sarah Turbett, David Gaston, Melissa Gitman, Raymund Razonable, Sophia Koo, Kimberly Hanson, et al. “A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients.Am J Transplant 22, no. 12 (December 2022): 3150–69. https://doi.org/10.1111/ajt.17147.
Azar MM, Turbett S, Gaston D, Gitman M, Razonable R, Koo S, et al. A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients. Am J Transplant. 2022 Dec;22(12):3150–69.
Azar, Marwan M., et al. “A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients.Am J Transplant, vol. 22, no. 12, Dec. 2022, pp. 3150–69. Pubmed, doi:10.1111/ajt.17147.
Azar MM, Turbett S, Gaston D, Gitman M, Razonable R, Koo S, Hanson K, Kotton C, Silveira F, Banach DB, Basu SS, Bhaskaran A, Danziger-Isakov L, Bard JD, Gandhi R, Hanisch B, John TM, Odom John AR, Letourneau AR, Luong M-L, Maron G, Miller S, Prinzi A, Schwartz I, Simner P, Kumar D, Transplant ID Diagnostics Consensus Conference Working Group. A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients. Am J Transplant. 2022 Dec;22(12):3150–3169.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

December 2022

Volume

22

Issue

12

Start / End Page

3150 / 3169

Location

United States

Related Subject Headings

  • Transplants
  • Transplant Recipients
  • Surgery
  • Organ Transplantation
  • North America
  • Humans
  • Consensus
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences