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Compartmentalization and regulation of GTP in control of cellular phenotypes.

Publication ,  Journal Article
Wolff, DW; Bianchi-Smiraglia, A; Nikiforov, MA
Published in: Trends Mol Med
September 2022

Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current Review, we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.

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Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

September 2022

Volume

28

Issue

9

Start / End Page

758 / 769

Location

England

Related Subject Headings

  • Phenotype
  • Immunology
  • Humans
  • Guanosine Triphosphate
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Wolff, D. W., Bianchi-Smiraglia, A., & Nikiforov, M. A. (2022). Compartmentalization and regulation of GTP in control of cellular phenotypes. Trends Mol Med, 28(9), 758–769. https://doi.org/10.1016/j.molmed.2022.05.012
Wolff, David W., Anna Bianchi-Smiraglia, and Mikhail A. Nikiforov. “Compartmentalization and regulation of GTP in control of cellular phenotypes.Trends Mol Med 28, no. 9 (September 2022): 758–69. https://doi.org/10.1016/j.molmed.2022.05.012.
Wolff DW, Bianchi-Smiraglia A, Nikiforov MA. Compartmentalization and regulation of GTP in control of cellular phenotypes. Trends Mol Med. 2022 Sep;28(9):758–69.
Wolff, David W., et al. “Compartmentalization and regulation of GTP in control of cellular phenotypes.Trends Mol Med, vol. 28, no. 9, Sept. 2022, pp. 758–69. Pubmed, doi:10.1016/j.molmed.2022.05.012.
Wolff DW, Bianchi-Smiraglia A, Nikiforov MA. Compartmentalization and regulation of GTP in control of cellular phenotypes. Trends Mol Med. 2022 Sep;28(9):758–769.
Journal cover image

Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

September 2022

Volume

28

Issue

9

Start / End Page

758 / 769

Location

England

Related Subject Headings

  • Phenotype
  • Immunology
  • Humans
  • Guanosine Triphosphate
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences