Compartmentalization and regulation of GTP in control of cellular phenotypes.

Journal Article (Journal Article;Review)

Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current Review, we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.

Full Text

Duke Authors

Cited Authors

  • Wolff, DW; Bianchi-Smiraglia, A; Nikiforov, MA

Published Date

  • September 2022

Published In

Volume / Issue

  • 28 / 9

Start / End Page

  • 758 - 769

PubMed ID

  • 35718686

Pubmed Central ID

  • PMC9420775

Electronic International Standard Serial Number (EISSN)

  • 1471-499X

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2022.05.012

Language

  • eng

Conference Location

  • England