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Genetics of common forms of heart failure: challenges and potential solutions.

Publication ,  Journal Article
Rau, CD; Lusis, AJ; Wang, Y
Published in: Curr Opin Cardiol
May 2015

PURPOSE OF REVIEW: In contrast to many other human diseases, the use of genome-wide association studies (GWAS) to identify genes for heart failure (HF) has had limited success. We will discuss the underlying challenges as well as potential new approaches to understanding the genetics of common forms of HF. RECENT FINDINGS: Recent research using intermediate phenotypes, more detailed and quantitative stratification of HF symptoms, founder populations and novel animal models has begun to allow researchers to make headway toward explaining the genetics underlying HF using GWAS techniques. SUMMARY: By expanding analyses of HF to improved clinical traits, additional HF classifications and innovative model systems, the intractability of human HF GWAS should be ameliorated significantly.

Duke Scholars

Published In

Curr Opin Cardiol

DOI

EISSN

1531-7080

Publication Date

May 2015

Volume

30

Issue

3

Start / End Page

222 / 227

Location

United States

Related Subject Headings

  • Phenotype
  • Humans
  • Heart Failure
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Rau, C. D., Lusis, A. J., & Wang, Y. (2015). Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol, 30(3), 222–227. https://doi.org/10.1097/HCO.0000000000000160
Rau, Christoph D., Aldons J. Lusis, and Yibin Wang. “Genetics of common forms of heart failure: challenges and potential solutions.Curr Opin Cardiol 30, no. 3 (May 2015): 222–27. https://doi.org/10.1097/HCO.0000000000000160.
Rau CD, Lusis AJ, Wang Y. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May;30(3):222–7.
Rau, Christoph D., et al. “Genetics of common forms of heart failure: challenges and potential solutions.Curr Opin Cardiol, vol. 30, no. 3, May 2015, pp. 222–27. Pubmed, doi:10.1097/HCO.0000000000000160.
Rau CD, Lusis AJ, Wang Y. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May;30(3):222–227.

Published In

Curr Opin Cardiol

DOI

EISSN

1531-7080

Publication Date

May 2015

Volume

30

Issue

3

Start / End Page

222 / 227

Location

United States

Related Subject Headings

  • Phenotype
  • Humans
  • Heart Failure
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology