Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.
Journal Article (Journal Article;Review)
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
- Gao, C; Wang, Y
Volume / Issue
- 78 / 5
Start / End Page
- 1038 - 1047
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)