Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.

Journal Article (Journal Article;Review)

With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.

Full Text

Duke Authors

Cited Authors

  • Gao, C; Wang, Y

Published Date

  • 2014

Published In

Volume / Issue

  • 78 / 5

Start / End Page

  • 1038 - 1047

PubMed ID

  • 24759793

Pubmed Central ID

  • PMC4306672

Electronic International Standard Serial Number (EISSN)

  • 1347-4820

Digital Object Identifier (DOI)

  • 10.1253/circj.cj-14-0412


  • eng

Conference Location

  • Japan