Global impact of RNA splicing on transcriptome remodeling in the heart.

Journal Article (Journal Article;Review)

In the eukaryotic transcriptome, both the numbers of genes and different RNA species produced by each gene contribute to the overall complexity. These RNA species are generated by the utilization of different transcriptional initiation or termination sites, or more commonly, from different messenger RNA (mRNA) splicing events. Among the 30,000+ genes in human genome, it is estimated that more than 95% of them can generate more than one gene product via alternative RNA splicing. The protein products generated from different RNA splicing variants can have different intracellular localization, activity, or tissue-distribution. Therefore, alternative RNA splicing is an important molecular process that contributes to the overall complexity of the genome and the functional specificity and diversity among different cell types. In this review, we will discuss current efforts to unravel the full complexity of the cardiac transcriptome using a deep-sequencing approach, and highlight the potential of this technology to uncover the global impact of RNA splicing on the transcriptome during development and diseases of the heart.

Full Text

Duke Authors

Cited Authors

  • Gao, C; Wang, Y

Published Date

  • August 2012

Published In

Volume / Issue

  • 13 / 8

Start / End Page

  • 603 - 608

PubMed ID

  • 22843179

Pubmed Central ID

  • PMC3411092

Electronic International Standard Serial Number (EISSN)

  • 1862-1783

Digital Object Identifier (DOI)

  • 10.1631/jzus.B1201006

Language

  • eng

Conference Location

  • China