Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.

Journal Article (Journal Article)

Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca(2+)-induced Ca(2+) release in the heart.

Full Text

Duke Authors

Cited Authors

  • Minamisawa, S; Oshikawa, J; Takeshima, H; Hoshijima, M; Wang, Y; Chien, KR; Ishikawa, Y; Matsuoka, R

Published Date

  • December 17, 2004

Published In

Volume / Issue

  • 325 / 3

Start / End Page

  • 852 - 856

PubMed ID

  • 15541368

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2004.10.107


  • eng

Conference Location

  • United States