Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.
Publication
, Journal Article
Minamisawa, S; Oshikawa, J; Takeshima, H; Hoshijima, M; Wang, Y; Chien, KR; Ishikawa, Y; Matsuoka, R
Published in: Biochem Biophys Res Commun
December 17, 2004
Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca(2+)-induced Ca(2+) release in the heart.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
December 17, 2004
Volume
325
Issue
3
Start / End Page
852 / 856
Location
United States
Related Subject Headings
- Myocytes, Cardiac
- Mice, Transgenic
- Mice, Inbred ICR
- Mice
- Membrane Proteins
- Heart Ventricles
- Gene Expression Regulation, Developmental
- Down-Regulation
- Disease Models, Animal
- Caveolins
Citation
APA
Chicago
ICMJE
MLA
NLM
Minamisawa, S., Oshikawa, J., Takeshima, H., Hoshijima, M., Wang, Y., Chien, K. R., … Matsuoka, R. (2004). Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun, 325(3), 852–856. https://doi.org/10.1016/j.bbrc.2004.10.107
Minamisawa, Susumu, Jin Oshikawa, Hiroshi Takeshima, Masahiko Hoshijima, Yibin Wang, Kenneth R. Chien, Yoshihiro Ishikawa, and Rumiko Matsuoka. “Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.” Biochem Biophys Res Commun 325, no. 3 (December 17, 2004): 852–56. https://doi.org/10.1016/j.bbrc.2004.10.107.
Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, et al. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17;325(3):852–6.
Minamisawa, Susumu, et al. “Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.” Biochem Biophys Res Commun, vol. 325, no. 3, Dec. 2004, pp. 852–56. Pubmed, doi:10.1016/j.bbrc.2004.10.107.
Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17;325(3):852–856.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
December 17, 2004
Volume
325
Issue
3
Start / End Page
852 / 856
Location
United States
Related Subject Headings
- Myocytes, Cardiac
- Mice, Transgenic
- Mice, Inbred ICR
- Mice
- Membrane Proteins
- Heart Ventricles
- Gene Expression Regulation, Developmental
- Down-Regulation
- Disease Models, Animal
- Caveolins