Long-Term Remissions of Patients With Follicular Lymphoma Grade 3 Treated With R-CHOP.
BACKGROUND: The optimal management of patients with follicular lymphoma Grade 3 (FLG3) is controversial. PATIENTS AND METHODS: This is a case series of 45 patients with FLG3 treated with first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and observed for an extended time interval. RESULTS: The overall response rate was 100% and the median progression-free survival (PFS) has not been reached, with a 3-year PFS of 70%; 14 (31%) patients relapsed, nearly all within 3 years. The baseline characteristic more strongly associated with a shorter PFS were lymph >4 node sites and presence of B symptoms. Three patients later progressed to diffuse large B cell lymphoma, all had baseline elevated serum lactate dehydrogenase level and high International Prognostic Index score. Median overall survival has not been reached. All 4 patients who later developed acute myeloid leukemia were older than 60 years at the time of start of therapy. CONCLUSION: R-CHOP is an effective first-line treatment for patients with FLG3, and might provide extended PFS, comparable with outcomes observed in diffuse large B-cell lymphoma, particularly in subgroups with limited nodal disease.
Duke Scholars
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Related Subject Headings
- Survival Analysis
- Prognosis
- Middle Aged
- Male
- Lymphoma, Follicular
- Humans
- Female
- Antineoplastic Combined Chemotherapy Protocols
- 3211 Oncology and carcinogenesis
- 3201 Cardiovascular medicine and haematology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Survival Analysis
- Prognosis
- Middle Aged
- Male
- Lymphoma, Follicular
- Humans
- Female
- Antineoplastic Combined Chemotherapy Protocols
- 3211 Oncology and carcinogenesis
- 3201 Cardiovascular medicine and haematology