Thermal ablation therapeutics based on CN(x) multi-walled nanotubes.

Journal Article (Journal Article)

We demonstrate that nitrogen doped, multi-walled carbon nanotubes (CN(x)-MWNT) result in photo-ablative destruction of kidney cancer cells when excited by near infrared (NIR) irradiation. Further, we show that effective heat transduction and cellular cytotoxicity depends on nanotube length: effective NIR coupling occurs at nanotube lengths that exceed half the wavelength of the stimulating radiation, as predicted in classical antenna theory. We also demonstrate that this radiation heats the nanotubes through induction processes, resulting in significant heat transfer to surrounding media and cell killing at extraordinarily small radiation doses. This cell death was attributed directly to photothermal effect generated within the culture, since neither the infrared irradiation itself nor the CN(x)-MWNT were toxic to the cells.

Full Text

Duke Authors

Cited Authors

  • Torti, SV; Byrne, F; Whelan, O; Levi, N; Ucer, B; Schmid, M; Torti, FM; Akman, S; Liu, J; Ajayan, PM; Nalamasu, O; Carroll, DL

Published Date

  • 2007

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 707 - 714

PubMed ID

  • 18203437

Pubmed Central ID

  • PMC2676813

International Standard Serial Number (ISSN)

  • 1176-9114


  • eng

Conference Location

  • New Zealand