Refractory metastatic breast cancer: salvage therapy with fluorouracil and high-dose continuous infusion leucovorin calcium.

Journal Article (Journal Article)

Sixty women with metastatic breast cancer refractory to at least one chemotherapeutic regimen were treated with fluorouracil (FUra) and high-dose continuous infusion folinic acid (leucovorin calcium). One complete remission lasting 8.7 months and nine partial remissions ranging in duration from 1.3 to 12.8 months were observed, for an objective response rate of 17% (95% confidence interval for response, 8% to 27%). Nine of the ten responding patients had metastatic disease that had objectively progressed on previous chemotherapy with a FUra-containing regimen. This program was well tolerated, with toxicities consisting mainly of stomatitis and granulocytopenia. These results suggest that augmentation of the reduced folate levels of metastatic breast carcinomas may enhance the effectiveness of the fluoropyrimidines in this disease.

Full Text

Duke Authors

Cited Authors

  • Doroshow, JH; Leong, L; Margolin, K; Flanagan, B; Goldberg, D; Bertrand, M; Akman, S; Carr, B; Odujinrin, O; Newman, E

Published Date

  • April 1989

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 439 - 444

PubMed ID

  • 2784492

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.1989.7.4.439


  • eng

Conference Location

  • United States