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Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract.

Publication ,  Journal Article
Margolin, K; Doroshow, J; Leong, L; Akman, S; Carr, BI; Odujinrin, O; Flanagan, B
Published in: Am J Clin Oncol
December 1989

Based on the demonstration of in vitro and in vivo synergy between cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP), we designed a Phase II trial of Ara-C plus CDDP for patients with advanced squamous cancers of the head and neck and esophagus. Sixteen patients were treated on a unique schedule of continuous-infusion Ara-C, 30 mg/m2/day over 72 h, plus CDDP, 30 mg/m2/day at hours 12, 36, and 60 of the Ara-C infusion. The objective response rate was 38% (95% confidence limits 14-62%), with two patients achieving complete clinical and radiographic response (9 and 27+ months duration) and four partial responses (median duration 4 months, range 1-7 months). There was no CDDP-related nephro- or neurotoxicities, but a flu-like syndrome of anorexia and asthenia was common. Myelosuppression was the dose-limiting toxicity, necessitating Ara-C dose adjustments in 11 cycles of therapy and leading to fatal sepsis in one patient. We conclude that the activity of this combination, though comparable to that of other CDDP-containing regimens, offers no significant therapeutic advantage, and given the excessive hematologic toxicity, should not be investigated further.

Published In

Am J Clin Oncol

DOI

ISSN

0277-3732

Publication Date

December 1989

Volume

12

Issue

6

Start / End Page

494 / 497

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Female
  • Esophageal Neoplasms
  • Drug Synergism
  • Drug Evaluation
  • Cytarabine
 

Citation

APA
Chicago
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MLA
NLM
Margolin, K., Doroshow, J., Leong, L., Akman, S., Carr, B. I., Odujinrin, O., & Flanagan, B. (1989). Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract. Am J Clin Oncol, 12(6), 494–497. https://doi.org/10.1097/00000421-198912000-00007
Margolin, K., J. Doroshow, L. Leong, S. Akman, B. I. Carr, O. Odujinrin, and B. Flanagan. “Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract.Am J Clin Oncol 12, no. 6 (December 1989): 494–97. https://doi.org/10.1097/00000421-198912000-00007.
Margolin K, Doroshow J, Leong L, Akman S, Carr BI, Odujinrin O, et al. Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract. Am J Clin Oncol. 1989 Dec;12(6):494–7.
Margolin, K., et al. “Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract.Am J Clin Oncol, vol. 12, no. 6, Dec. 1989, pp. 494–97. Pubmed, doi:10.1097/00000421-198912000-00007.
Margolin K, Doroshow J, Leong L, Akman S, Carr BI, Odujinrin O, Flanagan B. Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract. Am J Clin Oncol. 1989 Dec;12(6):494–497.

Published In

Am J Clin Oncol

DOI

ISSN

0277-3732

Publication Date

December 1989

Volume

12

Issue

6

Start / End Page

494 / 497

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Female
  • Esophageal Neoplasms
  • Drug Synergism
  • Drug Evaluation
  • Cytarabine