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A systems biology view of cancer.

Publication ,  Journal Article
Laubenbacher, R; Hower, V; Jarrah, A; Torti, SV; Shulaev, V; Mendes, P; Torti, FM; Akman, S
Published in: Biochim Biophys Acta
December 2009

In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy. Since the network is typically complex, with multiple connections between pathways and important feedback loops, it is crucial to represent it in the form of a computational model that can be used for a rigorous analysis. This is the approach of systems biology, made possible by new -omics data generation technologies. The goal of this review is to illustrate this approach and its utility for our understanding of cancer. After a discussion of recent progress using a network-centric approach, three case studies related to diagnostics, therapy, and drug development are presented in detail. They focus on breast cancer, B-cell lymphomas, and colorectal cancer. The discussion is centered on key mathematical and computational tools common to a systems biology approach.

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Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

December 2009

Volume

1796

Issue

2

Start / End Page

129 / 139

Location

Netherlands

Related Subject Headings

  • Systems Biology
  • Signal Transduction
  • Oncogenes
  • Neovascularization, Pathologic
  • Neoplasms
  • Neoplasm Metastasis
  • Lymphoma, B-Cell
  • Humans
  • Breast Neoplasms
  • Apoptosis
 

Citation

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Laubenbacher, R., Hower, V., Jarrah, A., Torti, S. V., Shulaev, V., Mendes, P., … Akman, S. (2009). A systems biology view of cancer. Biochim Biophys Acta, 1796(2), 129–139. https://doi.org/10.1016/j.bbcan.2009.06.001
Laubenbacher, Reinhard, Valerie Hower, Abdul Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti, and Steven Akman. “A systems biology view of cancer.Biochim Biophys Acta 1796, no. 2 (December 2009): 129–39. https://doi.org/10.1016/j.bbcan.2009.06.001.
Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, et al. A systems biology view of cancer. Biochim Biophys Acta. 2009 Dec;1796(2):129–39.
Laubenbacher, Reinhard, et al. “A systems biology view of cancer.Biochim Biophys Acta, vol. 1796, no. 2, Dec. 2009, pp. 129–39. Pubmed, doi:10.1016/j.bbcan.2009.06.001.
Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochim Biophys Acta. 2009 Dec;1796(2):129–139.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

December 2009

Volume

1796

Issue

2

Start / End Page

129 / 139

Location

Netherlands

Related Subject Headings

  • Systems Biology
  • Signal Transduction
  • Oncogenes
  • Neovascularization, Pathologic
  • Neoplasms
  • Neoplasm Metastasis
  • Lymphoma, B-Cell
  • Humans
  • Breast Neoplasms
  • Apoptosis