Skip to main content
Journal cover image

A general map of iron metabolism and tissue-specific subnetworks.

Publication ,  Journal Article
Hower, V; Mendes, P; Torti, FM; Laubenbacher, R; Akman, S; Shulaev, V; Torti, SV
Published in: Mol Biosyst
May 2009

Iron is required for survival of mammalian cells. Recently, understanding of iron metabolism and trafficking has increased dramatically, revealing a complex, interacting network largely unknown just a few years ago. This provides an excellent model for systems biology development and analysis. The first step in such an analysis is the construction of a structural network of iron metabolism, which we present here. This network was created using CellDesigner version 3.5.2 and includes reactions occurring in mammalian cells of numerous tissue types. The iron metabolic network contains 151 chemical species and 107 reactions and transport steps. Starting from this general model, we construct iron networks for specific tissues and cells that are fundamental to maintaining body iron homeostasis. We include subnetworks for cells of the intestine and liver, tissues important in iron uptake and storage, respectively, as well as the reticulocyte and macrophage, key cells in iron utilization and recycling. The addition of kinetic information to our structural network will permit the simulation of iron metabolism in different tissues as well as in health and disease.

Published In

Mol Biosyst

DOI

EISSN

1742-2051

Publication Date

May 2009

Volume

5

Issue

5

Start / End Page

422 / 443

Location

England

Related Subject Headings

  • Software
  • Reticulocytes
  • Metabolic Networks and Pathways
  • Macrophages
  • Iron
  • Biochemistry & Molecular Biology
  • Algorithms
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hower, V., Mendes, P., Torti, F. M., Laubenbacher, R., Akman, S., Shulaev, V., & Torti, S. V. (2009). A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst, 5(5), 422–443. https://doi.org/10.1039/b816714c
Hower, Valerie, Pedro Mendes, Frank M. Torti, Reinhard Laubenbacher, Steven Akman, Vladmir Shulaev, and Suzy V. Torti. “A general map of iron metabolism and tissue-specific subnetworks.Mol Biosyst 5, no. 5 (May 2009): 422–43. https://doi.org/10.1039/b816714c.
Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, et al. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009 May;5(5):422–43.
Hower, Valerie, et al. “A general map of iron metabolism and tissue-specific subnetworks.Mol Biosyst, vol. 5, no. 5, May 2009, pp. 422–43. Pubmed, doi:10.1039/b816714c.
Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009 May;5(5):422–443.
Journal cover image

Published In

Mol Biosyst

DOI

EISSN

1742-2051

Publication Date

May 2009

Volume

5

Issue

5

Start / End Page

422 / 443

Location

England

Related Subject Headings

  • Software
  • Reticulocytes
  • Metabolic Networks and Pathways
  • Macrophages
  • Iron
  • Biochemistry & Molecular Biology
  • Algorithms
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology