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Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study.

Publication ,  Journal Article
Hogan, WJ; Winter, S; Pinto, NM; Weng, C; Sheng, X; Conradt, E; Wood, J; Puchalski, MD; Tani, LY; Miller, TA
Published in: Dev Med Child Neurol
December 2018

AIM: To describe neurobehavioral patterns in neonates with congenital heart disease (CHD). METHOD: A cohort study describing neurobehavioral performance of neonates with CHD requiring cardiac surgery. The neonates were evaluated preoperatively and postoperatively with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) and scores were compared with published normative values. Clinical factors were obtained by chart review to assess their association with behavior. The CHD NNNS score pattern was compared with previously reported profiles in other high-risk populations. RESULTS: NNNS evaluations were completed on 67 neonates with CHD, resulting in 97 evaluations (50 preoperative, 47 postoperative). Compared with normative values, the cohort with CHD demonstrated decreased attention, regulation, asymmetry, stress, arousal, and excitability, along with increased non-optimal reflexes, lethargy, and need for handling (p<0.05 for all). Additional clinical factors had a minimal effect on the neurobehavioral pattern. Compared with previously published patterns in high-risk neonates without CHD, the cohort with CHD demonstrated a unique pattern of behavior. INTERPRETATION: Neonates with CHD demonstrate different neurobehavioral performance compared with typically developing neonates born at term as well as other high-risk neonates. Our experience suggests there is a unique neonatal neurobehavioral pattern in the hospitalized population with CHD. Targeted neonatal neurobehavioral evaluations may be useful in developing specific therapies to improve neurodevelopmental outcomes in neonates with CHD. WHAT THIS PAPER ADDS: Neonates with congenital heart disease demonstrate different neurobehavioral performance than typically developing neonates. Evaluation of neonatal neurobehavioral performance provides an opportunity to identify neurodevelopmental variability early. Identification of neurobehavioral performance variability allows targeted interactions and therapy.

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Published In

Dev Med Child Neurol

DOI

EISSN

1469-8749

Publication Date

December 2018

Volume

60

Issue

12

Start / End Page

1225 / 1231

Location

England

Related Subject Headings

  • Risk Factors
  • Psychomotor Disorders
  • Pediatrics
  • Neurologic Examination
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital
 

Citation

APA
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ICMJE
MLA
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Hogan, W. J., Winter, S., Pinto, N. M., Weng, C., Sheng, X., Conradt, E., … Miller, T. A. (2018). Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study. Dev Med Child Neurol, 60(12), 1225–1231. https://doi.org/10.1111/dmcn.13912
Hogan, Whitnee J., Sarah Winter, Nelangi M. Pinto, Cindy Weng, Xiaoming Sheng, Elisabeth Conradt, Janine Wood, Michael D. Puchalski, Lloyd Y. Tani, and Thomas A. Miller. “Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study.Dev Med Child Neurol 60, no. 12 (December 2018): 1225–31. https://doi.org/10.1111/dmcn.13912.
Hogan WJ, Winter S, Pinto NM, Weng C, Sheng X, Conradt E, et al. Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study. Dev Med Child Neurol. 2018 Dec;60(12):1225–31.
Hogan, Whitnee J., et al. “Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study.Dev Med Child Neurol, vol. 60, no. 12, Dec. 2018, pp. 1225–31. Pubmed, doi:10.1111/dmcn.13912.
Hogan WJ, Winter S, Pinto NM, Weng C, Sheng X, Conradt E, Wood J, Puchalski MD, Tani LY, Miller TA. Neurobehavioral evaluation of neonates with congenital heart disease: a cohort study. Dev Med Child Neurol. 2018 Dec;60(12):1225–1231.
Journal cover image

Published In

Dev Med Child Neurol

DOI

EISSN

1469-8749

Publication Date

December 2018

Volume

60

Issue

12

Start / End Page

1225 / 1231

Location

England

Related Subject Headings

  • Risk Factors
  • Psychomotor Disorders
  • Pediatrics
  • Neurologic Examination
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital