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The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure.

Publication ,  Journal Article
Conradt, E; Degarmo, D; Fisher, P; Abar, B; Lester, BM; Lagasse, LL; Shankaran, S; Bada, H; Bauer, CR; Whitaker, TM; Hammond, JA
Published in: Dev Psychopathol
November 2014

Neurobehavioral disinhibition (ND) is a complex condition reflecting a wide range of problems involving difficulties with emotion regulation and behavior control. Respiratory sinus arrhythmia (RSA) is a physiological correlate of emotion regulation that has been studied in a variety of at-risk populations; however, there are no studies of RSA in children with ND. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,073 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. ND was assessed at ages 8/9, 11, and 13/14 years via behavioral dysregulation and executive dysfunction composite measures. Greater exposure to early adversity was related to less RSA reactivity at 3 years, increases in RSA reactivity from ages 3 to 6 years, and increased behavioral dysregulation from ages 8/9 to 13/14. RSA reactivity was examined as a moderator of the association between early adversity and changes in ND. A significant Early Adversity × RSA Reactivity quadratic interaction revealed that children with decelerations in RSA reactivity exhibited increases in behavioral dysregulation, regardless of their exposure to early adversity. However, greater exposure to early adversity was related to greater increases in behavioral dysregulation, but only if children exhibited accelerations in RSA reactivity from ages 3 to 6 years. The results contribute to our understanding of how interactions across multiple levels of analysis contribute to the development of ND.

Duke Scholars

Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

November 2014

Volume

26

Issue

4 Pt 1

Start / End Page

901 / 916

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Respiratory Sinus Arrhythmia
  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Executive Function
 

Citation

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Conradt, E., Degarmo, D., Fisher, P., Abar, B., Lester, B. M., Lagasse, L. L., … Hammond, J. A. (2014). The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure. Dev Psychopathol, 26(4 Pt 1), 901–916. https://doi.org/10.1017/S095457941400056X
Conradt, Elisabeth, David Degarmo, Phil Fisher, Beau Abar, Barry M. Lester, Linda L. Lagasse, Seetha Shankaran, et al. “The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure.Dev Psychopathol 26, no. 4 Pt 1 (November 2014): 901–16. https://doi.org/10.1017/S095457941400056X.
Conradt, Elisabeth, et al. “The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure.Dev Psychopathol, vol. 26, no. 4 Pt 1, Nov. 2014, pp. 901–16. Pubmed, doi:10.1017/S095457941400056X.
Conradt E, Degarmo D, Fisher P, Abar B, Lester BM, Lagasse LL, Shankaran S, Bada H, Bauer CR, Whitaker TM, Hammond JA. The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure. Dev Psychopathol. 2014 Nov;26(4 Pt 1):901–916.
Journal cover image

Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

November 2014

Volume

26

Issue

4 Pt 1

Start / End Page

901 / 916

Location

United States

Related Subject Headings

  • Substance-Related Disorders
  • Respiratory Sinus Arrhythmia
  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Executive Function