Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain).

Journal Article (Journal Article)

Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.

Full Text

Duke Authors

Cited Authors

  • Nagajyothi, F; Desruisseaux, MS; Machado, FS; Upadhya, R; Zhao, D; Schwartz, GJ; Teixeira, MM; Albanese, C; Lisanti, MP; Chua, SC; Weiss, LM; Scherer, PE; Tanowitz, HB

Published Date

  • March 1, 2012

Published In

Volume / Issue

  • 205 / 5

Start / End Page

  • 830 - 840

PubMed ID

  • 22293433

Pubmed Central ID

  • PMC3274374

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jir840

Language

  • eng

Conference Location

  • United States