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New Insights Into Pentosan Polysulfate Maculopathy.

Publication ,  Conference
Abou-Jaoude, MM; Davis, AM; Fraser, CE; Leys, M; Hinkle, D; Odom, JV; Maldonado, RS
Published in: Ophthalmic Surg Lasers Imaging Retina
January 1, 2021

BACKGROUND AND OBJECTIVE: To provide new insights into toxic maculopathy secondary to pentosan polysulfate (PPS) utilizing multimodal testing. PATIENTS AND METHODS: Retrospective case-series of four patients from two academic centers evaluated with multimodal imaging, electrophysiology, dark adaptometry (DA), and genetic testing. RESULTS: Median age was 58 years, exposure to PPS was 18.5 years, and cumulative dose of was 2,025 grams. Seven of eight eyes had visual acuity of 20/40 or better. Optical coherence tomography (OCT) angiography demonstrated increased choriocapillaris flow voids (54.25%) in cases compared to controls (13.2%). Two subjects had abnormal foveal avascular zone configurations. Two subjects demonstrated collapse of the retinal pigment epithelium nodular excrescences and progressive retinal thinning over 4 to 5 years on OCT. Electrophysiology was normal (3/3 patients), but DA was delayed (2/2 patients). CONCLUSIONS: The authors describe novel findings of PPS maculopathy, including flow voids in the choriocapillaris. Progressive retinal thinning may suggest a secondary retinal effect. These findings may improve understanding of the pathophysiology. [Ophthalmic Surg Lasers Imaging Retina. 2021;52:13-22.].

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Published In

Ophthalmic Surg Lasers Imaging Retina

DOI

EISSN

2325-8179

Publication Date

January 1, 2021

Volume

52

Issue

1

Start / End Page

13 / 22

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Retinal Pigment Epithelium
  • Retinal Diseases
  • Pentosan Sulfuric Polyester
  • Middle Aged
  • Macular Degeneration
  • Humans
 

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Abou-Jaoude, M. M., Davis, A. M., Fraser, C. E., Leys, M., Hinkle, D., Odom, J. V., & Maldonado, R. S. (2021). New Insights Into Pentosan Polysulfate Maculopathy. In Ophthalmic Surg Lasers Imaging Retina (Vol. 52, pp. 13–22). United States. https://doi.org/10.3928/23258160-20201223-04
Abou-Jaoude, Michelle M., Alexander M. Davis, Claire E. Fraser, Monique Leys, David Hinkle, J Vernon Odom, and Ramiro S. Maldonado. “New Insights Into Pentosan Polysulfate Maculopathy.” In Ophthalmic Surg Lasers Imaging Retina, 52:13–22, 2021. https://doi.org/10.3928/23258160-20201223-04.
Abou-Jaoude MM, Davis AM, Fraser CE, Leys M, Hinkle D, Odom JV, et al. New Insights Into Pentosan Polysulfate Maculopathy. In: Ophthalmic Surg Lasers Imaging Retina. 2021. p. 13–22.
Abou-Jaoude, Michelle M., et al. “New Insights Into Pentosan Polysulfate Maculopathy.Ophthalmic Surg Lasers Imaging Retina, vol. 52, no. 1, 2021, pp. 13–22. Pubmed, doi:10.3928/23258160-20201223-04.
Abou-Jaoude MM, Davis AM, Fraser CE, Leys M, Hinkle D, Odom JV, Maldonado RS. New Insights Into Pentosan Polysulfate Maculopathy. Ophthalmic Surg Lasers Imaging Retina. 2021. p. 13–22.

Published In

Ophthalmic Surg Lasers Imaging Retina

DOI

EISSN

2325-8179

Publication Date

January 1, 2021

Volume

52

Issue

1

Start / End Page

13 / 22

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Retinal Pigment Epithelium
  • Retinal Diseases
  • Pentosan Sulfuric Polyester
  • Middle Aged
  • Macular Degeneration
  • Humans