TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors.

Journal Article (Journal Article)

The expression of transient receptor potential canonical 6 (TRPC6) in central nervous system (CNS) is important for neuronal functions and certain neural disorders. However, the regulatory mechanism of TRPC6 expression in neurons is still obscure. In this study, we show that TRPC6 expression in the primary cultured cortical neurons is bidirectionally regulated by glutamate. Activation of NR2A-containing NMDARs induces TRPC6 transcription through a calcineurin-dependent pathway. In contrast, activation of NR2B-containing NMDARs causes TRPC6 degradation through calpain. Thus, TRPC6 expression in neurons is regulated by glutamate in a bidirectional manner that is dependent on NR2A and NR2B.

Full Text

Duke Authors

Cited Authors

  • Qu, Z; Wang, Y; Li, X; Wu, L; Wang, Y

Published Date

  • November 2017

Published In

Volume / Issue

  • 143 / 3

Start / End Page

  • 282 - 293

PubMed ID

  • 28902407

Electronic International Standard Serial Number (EISSN)

  • 1471-4159

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/jnc.14215


  • eng