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Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome.

Publication ,  Journal Article
Horiuchi, Y; Wettersten, N; Patel, MP; Mueller, C; Neath, S-X; Christenson, RH; Morgenthaler, NG; McCord, J; Nowak, RM; Vilke, GM; Daniels, LB ...
Published in: Coron Artery Dis
August 1, 2022

BACKGROUND: Cardiac troponin (cTn) can be elevated in many patients presenting to the emergency department (ED) with chest pain but without a diagnosis of acute coronary syndrome (ACS). We compared the prognostic significance of cTn in these different populations. METHODS: We retrospectively analyzed the CHOPIN study, which enrolled patients who presented to the ED with chest pain. Patients were grouped as ACS, non-ACS cardiovascular disease, noncardiac chest pain and chest pain not otherwise specified (NOS). We examined the prognostic ability of cTnI for the clinical endpoints of mortality and major adverse cardiovascular event (MACE; a composite of acute myocardial infarction, unstable angina, revascularization, reinfarction, and congestive heart failure and stroke) at 180-day follow-up. RESULTS: Among 1982 patients analyzed, 14% had ACS, 21% had non-ACS cardiovascular disease, 31% had a noncardiac diagnosis and 34% had chest pain NOS. cTnI elevation above the 99th percentile was observed in 52, 18, 6 and 7% in these groups, respectively. cTnI elevation was associated with mortality and MACE, and their relationships were more prominent in noncardiac diagnosis and chest pain NOS than in ACS and non-ACS cardiovascular diagnoses for mortality, and in non-ACS patients than in ACS patients for MACE (hazard ratio for doubling of cTnI 1.85, 2.05, 8.26 and 4.14, respectively; P for interaction 0.011 for mortality; 1.04, 1.23, 1.54 and 1.42, respectively; P for interaction <0.001 for MACE). CONCLUSION: In patients presenting to the ED with chest pain, cTnI elevation was associated with a worse prognosis in non-ACS patients than in ACS patients.

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Published In

Coron Artery Dis

DOI

EISSN

1473-5830

Publication Date

August 1, 2022

Volume

33

Issue

5

Start / End Page

376 / 384

Location

England

Related Subject Headings

  • Troponin I
  • Retrospective Studies
  • Prognosis
  • Humans
  • Emergency Service, Hospital
  • Chest Pain
  • Cardiovascular System & Hematology
  • Biomarkers
  • Acute Coronary Syndrome
  • 3202 Clinical sciences
 

Citation

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Horiuchi, Y., Wettersten, N., Patel, M. P., Mueller, C., Neath, S.-X., Christenson, R. H., … Maisel, A. (2022). Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis, 33(5), 376–384. https://doi.org/10.1097/MCA.0000000000001135
Horiuchi, Yu, Nicholas Wettersten, Mitul P. Patel, Christian Mueller, Sean-Xavier Neath, Robert H. Christenson, Nils G. Morgenthaler, et al. “Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome.Coron Artery Dis 33, no. 5 (August 1, 2022): 376–84. https://doi.org/10.1097/MCA.0000000000001135.
Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath S-X, Christenson RH, et al. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022 Aug 1;33(5):376–84.
Horiuchi, Yu, et al. “Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome.Coron Artery Dis, vol. 33, no. 5, Aug. 2022, pp. 376–84. Pubmed, doi:10.1097/MCA.0000000000001135.
Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath S-X, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022 Aug 1;33(5):376–384.

Published In

Coron Artery Dis

DOI

EISSN

1473-5830

Publication Date

August 1, 2022

Volume

33

Issue

5

Start / End Page

376 / 384

Location

England

Related Subject Headings

  • Troponin I
  • Retrospective Studies
  • Prognosis
  • Humans
  • Emergency Service, Hospital
  • Chest Pain
  • Cardiovascular System & Hematology
  • Biomarkers
  • Acute Coronary Syndrome
  • 3202 Clinical sciences