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White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation.

Publication ,  Journal Article
Zhou, Z; Domel, AG; Li, X; Grant, G; Kleiven, S; Camarillo, D; Zeineh, M
Published in: J Neurotrauma
June 15, 2021

Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction of white matter (WM) tracts (i.e., tract-oriented strain) has been shown to be an appropriate predictor for TAI. The evolution of fiber orientation in time during the impact and its potential influence on the tract-oriented strain remains unknown, however. To address this question, the present study leveraged an embedded element approach to track real-time fiber orientation during impacts. A new scheme to calculate the tract-oriented strain was proposed by projecting the strain tensors from pre-computed simulations along the temporal fiber direction instead of its static counterpart directly obtained from diffuse tensor imaging. The results revealed that incorporating the real-time fiber orientation not only altered the direction but also amplified the magnitude of the tract-oriented strain, resulting in a generally more extended distribution and a larger volume ratio of WM exposed to high deformation along fiber tracts. These effects were exacerbated with the impact severities characterized by the acceleration magnitudes. Results of this study provide insights into how best to incorporate fiber orientation in head injury models and derive the WM tract-oriented deformation from computational simulations, which is important for furthering our understanding of the underlying mechanisms of TAI.

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Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

June 15, 2021

Volume

38

Issue

12

Start / End Page

1730 / 1745

Location

United States

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Models, Neurological
  • Humans
  • Finite Element Analysis
  • Brain Injuries, Traumatic
  • Axons
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Zhou, Z., Domel, A. G., Li, X., Grant, G., Kleiven, S., Camarillo, D., & Zeineh, M. (2021). White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation. J Neurotrauma, 38(12), 1730–1745. https://doi.org/10.1089/neu.2020.7412
Zhou, Zhou, August G. Domel, Xiaogai Li, Gerald Grant, Svein Kleiven, David Camarillo, and Michael Zeineh. “White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation.J Neurotrauma 38, no. 12 (June 15, 2021): 1730–45. https://doi.org/10.1089/neu.2020.7412.
Zhou Z, Domel AG, Li X, Grant G, Kleiven S, Camarillo D, et al. White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation. J Neurotrauma. 2021 Jun 15;38(12):1730–45.
Zhou, Zhou, et al. “White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation.J Neurotrauma, vol. 38, no. 12, June 2021, pp. 1730–45. Pubmed, doi:10.1089/neu.2020.7412.
Zhou Z, Domel AG, Li X, Grant G, Kleiven S, Camarillo D, Zeineh M. White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation. J Neurotrauma. 2021 Jun 15;38(12):1730–1745.
Journal cover image

Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

June 15, 2021

Volume

38

Issue

12

Start / End Page

1730 / 1745

Location

United States

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Models, Neurological
  • Humans
  • Finite Element Analysis
  • Brain Injuries, Traumatic
  • Axons
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences