Rapid Estimation of Entire Brain Strain Using Deep Learning Models.

Journal Article (Journal Article)

OBJECTIVE: Many recent studies suggest that brain deformation resulting from head impacts are linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even if several finite element (FE) head models have been developed and validated to calculate brain deformation based on impact kinematics, the clinical application of these FE head models is limited due to the time-consuming nature of FE simulations. This work aims to accelerate the brain deformation calculation and thus improve the potential for clinical applications. METHODS: We propose a deep learning head model with a five-layer deep neural network and feature engineering, and trained and tested the model on 2511 head impacts from a combination of head model simulations and on-field college football and mixed martial arts impacts. RESULTS: The proposed deep learning head model can calculate the maximum principal strain (Green Lagrange) for every element in the entire brain in less than 0.001 s with an average root mean squared error of 0.022 and a standard deviation of 0.001 over twenty repeats with random data partition and model initialization. CONCLUSION: Trained and tested using the dataset of 2511 head impacts, this model can be applied to various sports in the calculation of brain strain with accuracy, and its applicability can even further be extended by incorporating data from other types of head impacts. SIGNIFICANCE: In addition to the potential clinical application in real-time brain deformation monitoring, this model will help researchers estimate the brain strain from a large number of head impacts more efficiently than using FE models.

Full Text

Duke Authors

Cited Authors

  • Zhan, X; Liu, Y; Raymond, S; Vahid Alizadeh, H; Domel, A; Gevaert, O; Zeineh, M; Grant, G; Camarillo, D

Published Date

  • November 2021

Published In

Volume / Issue

  • 68 / 11

Start / End Page

  • 3424 - 3434

PubMed ID

  • 33852381

Electronic International Standard Serial Number (EISSN)

  • 1558-2531

Digital Object Identifier (DOI)

  • 10.1109/TBME.2021.3073380

Language

  • eng

Conference Location

  • United States