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Recurrence of cavernous malformations after surgery in childhood.

Publication ,  Journal Article
Prolo, LM; Jin, MC; Loven, T; Vogel, H; Edwards, MSB; Steinberg, GK; Grant, GA
Published in: J Neurosurg Pediatr
May 1, 2020

OBJECTIVE: Cavernous malformations (CMs) are commonly treated cerebrovascular anomalies in the pediatric population; however, the data on radiographic recurrence of pediatric CMs after surgery are limited. The authors aimed to study the clinical presentation, outcomes, and recurrence rate following surgery for a large cohort of CMs in children. METHODS: Pediatric patients (≤ 18 years old) who had a CM resected at a single institution were identified and retrospectively reviewed. Fisher's exact test of independence was used to assess differences in categorical variables. Survival curves were evaluated using the Mantel-Cox method. RESULTS: Fifty-three patients aged 3 months to 18 years underwent resection of 74 symptomatic CMs between 1996 and 2018 at a single institution. The median length of follow-up was 5.65 years. Patients most commonly presented with seizures (45.3%, n = 24) and the majority of CMs were cortical (58.0%, n = 43). Acute radiographic hemorrhage was common at presentation (64.2%, n = 34). Forty-two percent (n = 22) of patients presented with multiple CMs, and they were more likely to develop de novo lesions (71%) compared to patients presenting with a single CM (3.4%). Both radiographic hemorrhage and multiple CMs were independently prognostic for a higher risk of the patient requiring subsequent surgery. Fifty percent (n = 6) of the 12 patients with both risk factors required additional surgery within 2.5 years of initial surgery compared to none of the patients with neither risk factor (n = 9). CONCLUSIONS: Patients with either acute radiographic hemorrhage or multiple CMs are at higher risk for subsequent surgery and require long-term MRI surveillance. In contrast, patients with a single CM are unlikely to require additional surgery and may require less frequent routine imaging.

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Published In

J Neurosurg Pediatr

DOI

EISSN

1933-0715

Publication Date

May 1, 2020

Volume

26

Issue

2

Start / End Page

179 / 188

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 3213 Paediatrics
  • 3209 Neurosciences
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Prolo, L. M., Jin, M. C., Loven, T., Vogel, H., Edwards, M. S. B., Steinberg, G. K., & Grant, G. A. (2020). Recurrence of cavernous malformations after surgery in childhood. J Neurosurg Pediatr, 26(2), 179–188. https://doi.org/10.3171/2020.2.PEDS19543
Prolo, Laura M., Michael C. Jin, Tina Loven, Hannes Vogel, Michael S. B. Edwards, Gary K. Steinberg, and Gerald A. Grant. “Recurrence of cavernous malformations after surgery in childhood.J Neurosurg Pediatr 26, no. 2 (May 1, 2020): 179–88. https://doi.org/10.3171/2020.2.PEDS19543.
Prolo LM, Jin MC, Loven T, Vogel H, Edwards MSB, Steinberg GK, et al. Recurrence of cavernous malformations after surgery in childhood. J Neurosurg Pediatr. 2020 May 1;26(2):179–88.
Prolo, Laura M., et al. “Recurrence of cavernous malformations after surgery in childhood.J Neurosurg Pediatr, vol. 26, no. 2, May 2020, pp. 179–88. Pubmed, doi:10.3171/2020.2.PEDS19543.
Prolo LM, Jin MC, Loven T, Vogel H, Edwards MSB, Steinberg GK, Grant GA. Recurrence of cavernous malformations after surgery in childhood. J Neurosurg Pediatr. 2020 May 1;26(2):179–188.

Published In

J Neurosurg Pediatr

DOI

EISSN

1933-0715

Publication Date

May 1, 2020

Volume

26

Issue

2

Start / End Page

179 / 188

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 3213 Paediatrics
  • 3209 Neurosciences
  • 1114 Paediatrics and Reproductive Medicine