Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging.

Journal Article (Journal Article;Review)

The United States is undergoing a demographic shift towards an older population with profound economic, social, and healthcare implications. The number of Americans aged 65 and older will reach 80 million by 2040. The shift will be even more dramatic in the extremes of age, with a projected 400% increase in the population over 85 years old in the next two decades. Understanding the molecular and cellular mechanisms of ageing is crucial to reduce ageing-associated disease and to improve the quality of life for the elderly. In this review, we summarized the changes associated with the ageing of hematopoietic stem cells (HSCs) and what is known about some of the key underlying cellular and molecular pathways. We focus here on the effects of reactive oxygen species and the thioredoxin redox homeostasis system on ageing biology in HSCs and the HSC microenvironment. We present additional data from our lab demonstrating the key role of thioredoxin-1 in regulating HSC ageing.

Full Text

Duke Authors

Cited Authors

  • Jabbar, S; Mathews, P; Kang, Y

Published Date

  • June 29, 2022

Published In

Volume / Issue

  • 11 / 7

PubMed ID

  • 35883782

Pubmed Central ID

  • PMC9312246

International Standard Serial Number (ISSN)

  • 2076-3921

Digital Object Identifier (DOI)

  • 10.3390/antiox11071291

Language

  • eng

Conference Location

  • Switzerland